POS0116 HEART RATE VARIABILITY IN PATIENTS WITH BEHCETS DISEASE

Background: Behcet’s disease (BD) is a systemic vasculitis affecting all types and sizes of blood vessels. Heart rate variability (HRV) reflects sympathetic -parasympathetic imbalance in the autonomic NS regulation. Low HRV values are known as independent risk factor death non-fatal cardiovascular events both - survivors myocardial infarction asymptomatic population. Objectives: The aim this study to evaluate BD pts vs healthy controls. Methods: group included 74 (53males/21females) with duration 9,0 (5,0;15,0)/9,0 (7;20) years, control 32/15 age-matched m/f. following parameters from 24h ECG ambulatory recording were assessed: MeanNN time-domain variables, adjusted by (SDNNn%, SDNNin%, RMSSDn%). Additionally, traditional factors such systolic pressure (SPB), smoking status, BMI values, dyslipidemia profile, ultrasonographic carotid intima-media thickness (IMT), levels high sensitive CRP (hsCRP) marker inflammation evaluated. Results: In patients (RMSSDn%) significantly lower compared controls (table 1). Table 1. Parameters Males Females (n=53) Control (n=32) (n=21) (n=15) Age, years 30 (24; 36) (26; 35) 32 37) 28 31) MeanNN, ms 810 (732; 849) 782 835) 776 (708; 830) 764 (694; 832) SDNN n (%) 16,9 (13,6; 19,4) 17,2 (16,3; 21,1) 13,1 (11,3; 5,3) 12,2 (10,7; 14,6) SDNNi 6,8 (5,1; 8,1) (5,0; 8,3) 7,1 (6,1; 7,7) 5,2 (4,9; 5,7) RMSSD 2,1 (1,5; 2,3)** 4,1 (2,7; 5,2)** 1,7 (1,4; 3,7)* 2,8 (2,2; 3,9)* Data presented median interquartile range, *p<0,05, **p<0,005 There was significant negative correlation between (SDNNin%) age (r= -0,4; p =0,00), -0,3; -0,2; <0,01), cholesterol LDLP =0,00) increased IMT =0,04), also (RMSSD%) =0,01), HDLP =0,04); positive established (SNNN%) =0,04). showed 0,4; =0,01). Conclusion: reduction impaired regulation pts, associated pts’ age, presence factors: BMI, levels, LDLP, manifestation atherosclerosis IMT. Disclosure Interests: None declared